Depression trials in United States

In United States 272 Also abroad 666

272 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder
Where
Durham
Age
22 years and over
People
214
Run by
Pulvinar Neuro, LLC
See details and how to joinNCT07282678
Phase 2Taking people
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
Where
Atlanta, Austin, Bellevue, Bentonville, Decatur, DeSoto, Flowood, Gaithersburg, Las Vegas, Little Rock, Marlton, Media, Miami, New Port Richey, New York, Oceanside, Orlando, Richardson, San Diego, Torrance, Watertown, Wichita Falls
Age
18 years to 75 years
People
300 worldwide
Run by
Draig Therapeutics Ltd
See details and how to joinNCT07300969
No phaseTaking people
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
Where
Bethesda
Age
8 years to 70 years
People
1,260
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT05669703
Early phase 1Taking people
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine
Where
Philadelphia
Age
25 years to 65 years
People
10
Run by
University of Pennsylvania
See details and how to joinNCT06788249
No phaseTaking people
Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms
Where
Boston
Age
18 years and over
People
70
Run by
Massachusetts General Hospital
See details and how to joinNCT07610928
No phaseNot yet taking people in United States
Youth Suicide Prevention: CAMS-BI vs. Safety Planning in a Randomized Trial
Where
Cleveland
Age
12 years to 17 years
People
118
Run by
The Cleveland Clinic
See details and how to joinNCT07628192
No phaseTaking people
Mindfulness Training During Accelerated TMS for Depression
Where
Charleston
Age
18 years to 80 years
People
20
Run by
Medical University of South Carolina
See details and how to joinNCT07369557
Phase 2Taking people
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
Where
Bethesda
Age
18 years to 70 years
People
50
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT06511908
No phaseTaking people
Long-term Observation of Participants With Mood Disorders
Where
Bethesda
Age
18 years to 99 years
People
1,000
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT04877977
Phase 1Taking people
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
Where
Bethesda
Age
18 years to 70 years
People
108
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT05703685
No phaseTaking people
Development of Attentional Biases for Affective Cues in Infants of Mothers With Depression
Where
Binghamton
Age
6 months and over
People
225
Run by
Binghamton University
See details and how to joinNCT06835855
No phaseEnrolling by invitation
Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness
Where
Providence
Age
18 years and over
People
180
Run by
Butler Hospital
See details and how to joinNCT05703412
Phase 2Taking people
Precision Depression Adalimumab Trial
Where
Philadelphia
Age
18 years and over
People
60
Run by
Daniel Moriarity
See details and how to joinNCT07845604
Phase 2Taking people
JAK Signaling in Depression
Where
Atlanta
Age
25 years to 55 years
People
100
Run by
Emory University
See details and how to joinNCT07003997
Phase 3Enrolling by invitation
Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)
Where
Atlanta, Boston, Canton, Chicago, Denver, DeSoto, Draper, Eden Prairie, Evergreen, Glendale, Hollywood, Houston, Jacksonville, Lady Lake, La Jolla, Las Vegas, Lauderhill, Los Angeles, Maitland, Memphis, New York, Oceanside, Orlando, Philadelphia, Phoenix, Princeton, Rockville, San Francisco, San Juan Capistrano, Savannah, Skokie, Springfield, The Bronx, Toms River, Watertown
Age
18 years to 85 years
People
468 worldwide
Run by
Cybin IRL Limited
See details and how to joinNCT06605105 · EU 2024-516805-22-00
Phase 1/2Taking people
tDCS for Late-Life Depression
Where
Dallas
Age
60 years and over
People
20
Run by
Andre Russowsky Brunoni
See details and how to joinNCT07657234
No phaseNot yet taking people in United States
Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation
Where
Lexington
Age
18 years to 75 years
People
60
Run by
University of Kentucky
See details and how to joinNCT07842601
No phaseEnrolling by invitation
Resonant Frequency rTMS: A Novel Approach to Target Circuit Modulation in Major Depressive Disorder
Where
Los Angeles
Age
21 years to 75 years
People
84
Run by
University of California, Los Angeles
See details and how to joinNCT06572683
Phase 3Taking people
Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
Where
Bellevue, Boston, Carmel, Charlotte, Chicago, Cincinnati, Colorado Springs, Fort Myers, Garden Grove, Houston, Las Vegas, Little Rock, Media, Miami, New York, Orange, Phoenix, Plano, Redlands, Richardson, Saint Charles, San Jose, Snellville, Staten Island, Tampa, Walnut Creek, Witchita Falls
Age
18 years to 65 years
People
500 worldwide
Run by
Vanda Pharmaceuticals
See details and how to joinNCT06830044 · EU 2024-520333-68-00
Phase 2Not yet taking people in United States
Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression
Where
Rochester
Age
18 years and over
People
25
Run by
University of Rochester
See details and how to joinNCT07247006
No phaseTaking people
Mobile Cognitive Behavioral Therapy in Early Stroke Recovery
Where
New York
Age
18 years to 79 years
People
10
Run by
Weill Medical College of Cornell University
See details and how to joinNCT07639606
No phaseTaking people
DBS for TRD With the Medtronic Percept PC
Where
New York
Age
25 years to 70 years
People
20
Run by
Helen Mayberg, MD
See details and how to joinNCT05773755
No phaseTaking people
The Medically Tailored Groceries and Mental Health Study
Where
Worcester
Age
18 years and over
People
300
Run by
University of Massachusetts, Worcester
See details and how to joinNCT07779707
No phaseTaking people
Singula Phase 0.1 Primary Care Pilot
Where
Brentwood, Mount Kisco
Age
18 years and over
People
100
Run by
Singula Health, Inc.
See details and how to joinNCT07834684
No phaseNot yet taking people in United States
Home-Based Randomized Trial of Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression
Where
San Diego
Age
18 years to 70 years
People
74
Run by
University of California, San Diego
See details and how to joinNCT07834762