Huntington's disease: trials for referral
51 open trials in the registries we read. Each row links to its registry record.
Registry data only. Frontlight does not judge whether a patient can take part: the trial team decides.
Where the open trials are
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51 trials shown
Phase 2/337 sites
RecruitingArgentina, Brazil, Canada, Chile, Colombia, Germany
NCT07378644
Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's Disease
Skyhawk Therapeutics, Inc.
Registry updated 6 Nov 2026
Registry record: ClinicalTrials.govPhase 366 sites
RecruitingBelgium, Canada, Czechia, Germany, Spain, France
NCT07609108
Pridopidine Phase 3 Study in Huntington's Disease
Prilenia
Registry updated 4 Nov 2026
Registry record: ClinicalTrials.govPhase 15 sites
RecruitingAustralia, Switzerland, United Kingdom, New Zealand
NCT07536061
A First-in-human Study of the Effects of SRP-1005 in Participants With Huntington's Disease
Sarepta Therapeutics, Inc.
Registry updated 19 Oct 2026
Registry record: ClinicalTrials.govPhase 119 sites
RecruitingCanada, Germany, United Kingdom
NCT06585449
A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease
Alnylam Pharmaceuticals
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.govPhase 3168 sites
RecruitingArgentina, Austria, Australia, Belgium, Bulgaria, Canada
NCT07326709
A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease
Novartis Pharmaceuticals
Registry updated 22 Sept 2026
Registry record: ClinicalTrials.govPhase 1/217 sites
RecruitingGermany, Denmark, France, United Kingdom, Israel, Netherlands
NCT05822908
A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD
Vico Therapeutics B. V.
Registry updated 19 Aug 2026
Registry record: ClinicalTrials.govPhase 2/310 sites
By invitation onlyAustralia, New Zealand
NCT07537075
An Extension of SKY-0515 in Participants With Huntington's Disease
Skyhawk Therapeutics, Inc.
Registry updated 24 Jul 2026
Registry record: ClinicalTrials.govPhase 33 sites
By invitation onlyCanada
NCT06312189
Long-term Study to Evaluate Safety and Tolerability of Valbenazine in Participants With Chorea Associated With Huntington Disease in Canada
Neurocrine Biosciences
Registry updated 18 Jun 2026
Registry record: ClinicalTrials.govPhase 1/25 sites
RecruitingUnited States
NCT06826612
A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease
Hoffmann-La Roche
Registry updated 5 May 2026
Registry record: ClinicalTrials.govPhase 1/21 site
RecruitingUnited States
NCT07451613
Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease
Leslie Thompson
Registry updated 13 Apr 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT06843252
Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease
The University of Texas Health Science Center at San Antonio
Registry updated 11 Feb 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT05326451
Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease
The University of Texas Health Science Center, Houston
Registry updated 11 Feb 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingBelgium
NCT07136844
Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology
Centre Hospitalier Universitaire de Liege
Registry updated 22 Aug 2025
Registry record: ClinicalTrials.govNo phase0 sites
Not yet recruiting
NCT06976983
Transcranial Static Magnetic Stimulation (tSMS) in Huntington's Disease (HD)
Neuromed IRCCS
Registry updated 16 May 2025
Registry record: ClinicalTrials.govPhase 25 sites
RecruitingAustralia
NCT05509153
A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers
Western Sydney Local Health District
Registry updated 28 Feb 2025
Registry record: ClinicalTrials.govPhase 23 sites
RecruitingSpain
NCT04478734
Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's Disease
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Registry updated 25 Feb 2025
Registry record: ClinicalTrials.govPhase 210 sites
Not yet recruitingGermany, Denmark, France, Netherlands
2026-526408-60-00
A Phase 2, open-label trial to investigate the long-term safety of VO659 administered intrathecally in participants with Huntington’s disease and spinocerebellar ataxia type 1 and 3
Vico Therapeutics B.V.
Registry updated 30 Oct 2026
Registry record: EU CTISNo phase1 site
Not yet recruitingSpain
NCT07902206
Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease
Universidad de Burgos
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT07280650
Feasibility and Acceptability of an LLM-based Chatbot for Family Caregivers: Evaluation Study
University of Michigan
Registry updated 26 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingFrance
NCT06147414
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
Assistance Publique - Hôpitaux de Paris
Registry updated 21 Oct 2026
Registry record: ClinicalTrials.govNo phase2 sites
Not yet recruitingUnited States
NCT07315984
Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease
BioSensics
Registry updated 13 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingItaly
NCT06782230
ScATtEred Rare Disease Biobanks: a Model of Sample/Data Collection With susTainablE and Shared Criteria
IRCCS Policlinico S. Donato
Registry updated 27 Aug 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT07010705
Digital Measures for Clinical Trial Endpoints in Huntington's Disease
University of Rochester
Registry updated 17 Aug 2026
Registry record: ClinicalTrials.govPhase 422 sites
RecruitingGermany
2023-503705-10-00
Patient- and care-related benefits of amyloid PET imaging (ENABLE)
Deutsches Zentrum Fuer Neurodegenerative Erkrankungen e.V.
Registry updated 17 Jul 2026
Registry record: EU CTISNo phase1 site
RecruitingChina
NCT07513844
Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease
First Affiliated Hospital of Fujian Medical University
Registry updated 29 Apr 2026
Registry record: ClinicalTrials.govNo phase40 sites
RecruitingCanada, Germany, Spain, France, United Kingdom, Italy
NCT02855476
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
University College, London
Registry updated 27 Apr 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruitingFrance
NCT07409597
Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease
University Hospital, Angers
Registry updated 6 Apr 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingFrance
NCT06807892
Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients
University Hospital, Angers
Registry updated 17 Mar 2026
Registry record: ClinicalTrials.govEarly Phase 11 site
RecruitingBelgium
NCT06634628
iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009
CHDI Foundation, Inc.
Registry updated 13 Mar 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingSweden
NCT07253038
Evaluation of Three Tests to Assess Social Cognition in Huntington Disease
Region Skane
Registry updated 11 Mar 2026
Registry record: ClinicalTrials.gov
The same sites as a list
- United States21 open trials
- France14 open trials
- Germany9 open trials
- United Kingdom9 open trials
- Spain7 open trials
- Netherlands7 open trials
- Canada6 open trials
- Italy5 open trials
- Belgium5 open trials
- Australia5 open trials
- Portugal4 open trials
- Poland4 open trials
- Denmark4 open trials
- New Zealand3 open trials
- Argentina2 open trials
- Colombia2 open trials
- Chile2 open trials
- Czechia2 open trials
- China2 open trials
- Sweden2 open trials
- Norway2 open trials
- Israel2 open trials
- Georgia1 open trial
- Brazil1 open trial
- Switzerland1 open trial
- Bulgaria1 open trial
- Romania1 open trial
- South Korea1 open trial
- Austria1 open trial
- Japan1 open trial
- Greece1 open trial
- Hungary1 open trial
- Finland1 open trial
- Ireland1 open trial
Who treats this
Institutions with trials or publications in this disease (OpenAlex, registries). Institutions only, no people.
Birmingham and Solihull Mental Health NHS Foundation Trust
Birmingham, United Kingdom
3 trials · 6 publications · ROR
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
1 trial · 8 publications · ROR
What changed in the last 7 days
Registry facts, one per line, newest first.
Status changed: Completed → Running, not recruiting
2024-518875-73-00 · Phase 3 · Spain
Source: EU CTISOpened for recruitment
NCT07378644 · Phase 2/3 · Argentina, Brazil, Canada, Chile, Colombia, Germany
Source: ClinicalTrials.govStatus changed: Completed → Running, not recruiting
NCT07246941 · Phase 1 · Argentina, Australia, Canada, Germany, Denmark, Spain
Source: ClinicalTrials.govPhase changed: Phase 1/2 → Phase 2
Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's Disease
NCT04478734 · Phase 2 · Spain
Source: ClinicalTrials.govStatus changed: Recruiting → Not yet recruiting
NCT07378644 · Phase 2/3 · Argentina, Brazil, Canada, Chile, Colombia, Germany
Source: ClinicalTrials.govPhase changed: No phase → Phase 3
Innovative Imaging and Cognitive BIOmarkers to Predict Huntington's Disease Progression
NCT05808153 · Phase 3 · France
Source: ClinicalTrials.gov
Results card
Trials that finished or stopped in the last 3 years, with the reason the registry gives and linked publications.
No phaseEnded 3 Jul 2026
Completed574 participants
NCT06667414
Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
No phaseEnded 31 Mar 2026
Completed488 participants
NCT01860339
Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease
No phaseEnded 31 Mar 2026
Withdrawn before start0 participants
NCT07299682
Facilitating Effective Eating With DoddleBags: A Single-Arm Acceptability Study Of DoddleBags to Assess Impact on Self Feeding Behaviours in a Huntington's Disease Population
Reason given: No recruitment
Early Phase 1Ended 31 Jan 2026
No phaseEnded 22 Dec 2025
Completed131 participants
NCT06343220
Project AWARE 2.0 to Improve Awareness, Willingness and Ability for Research and Enrollment in Clinical Research
No phaseEnded 17 Nov 2025
Completed20 participants
NCT06444217
Gene Therapy Development and Validation for Huntington's Disease Fibro TG-HD
Phase 3Ended 5 Nov 2025
Stopped early154 participants
NCT04400331
Open-Label Rollover Study for Continuing Valbenazine Administration for the Treatment of Chorea Associated With Huntington Disease
Reason given: Sponsor Decision
Phase 4Ended 24 Oct 2025
Completed50 participants
NCT07601516
Real World Effectiveness and Safety of Deutetrabenazine in Adult Chinese Participants With Huntington's Disease (HD) Chorea in China
Early Phase 1Ended 4 Sept 2025
Completed10 participants
NCT06024265
The Safety and Tolerability Study With ER2001 Intravenous Injection in Adults With Early Manifest Huntington's Disease
Phase 2Ended 31 Jul 2025
Completed159 participants
NCT05358717
A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)
Phase 3Ended 10 Jun 2025
No phaseEnded 30 May 2025
Completed22 participants
NCT06490367
Time-Restricted Eating in Huntington's Disease: A Clinical Pilot Study
No phaseEnded 31 Jan 2025
Phase 3Ended 20 Jan 2025
Stopped early153 participants
NCT05655520
A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Huntington's Disease
Reason given: Internal company decision
No phaseEnded 12 Jan 2025
Stopped early48 participants
NCT04394767
Couple and Spouse Caregiver in Huntington's Disease
Reason given: Sponsor's decision, no more inclusions made since the last extension
Phase 1Ended 30 Dec 2024
Withdrawn before start0 participants
NCT04885114
Safety and Tolerability Study With VY-HTT01, in Adults With Early Manifesting Huntington's Disease
Reason given: We have discontinued our 1st generation HD program with the VYTAL Study \& have initiated a 2nd generation program using a novel, proprietary AAV capsid that may enable intravenous administration \& achieve widespread distribution to affected tissue.
Phase 2Ended 4 Dec 2024
Completed10 participants
NCT06469853
Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of MBF-015 in Huntington's Disease Patients
Phase 2Ended 4 Dec 2024
No phaseEnded 14 Nov 2024
No phaseEnded 31 Oct 2024
Completed70 participants
NCT06585332
Handgrip and Respiratory Dysfunction in HD Patients.
- Handgrip strength and the Index of pulmonary dysfunction: Practical screening tools for cough dysfunction in huntington's disease. · Journal of Huntington's disease, 2026
Show more
Phase 2Ended 3 Oct 2024
Completed189 participants
NCT05107128
A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD)
Phase 2Ended 15 Jul 2024
Phase 1/2Ended 24 May 2024
No phaseEnded Apr 2024
No phaseEnded 12 Apr 2024
Phase 2Ended 10 Apr 2024
Completed69 participants
NCT05358821
28-Day Study of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease
Phase 3Ended 21 Mar 2024
Completed499 participants
NCT04556656
PRidopidine's Outcome On Function in Huntington Disease, PROOF- HD
No phaseEnded 5 Feb 2024
Completed150 participants
NCT04630574
Characterization and Quantification of Motor Speech Disorders in Huntington's Disease: Identification of Acoustic Markers
Phase 2Ended 30 Dec 2023
Completed6 participants
NCT04201834
Risperidone for the Treatment of Huntington's Disease Involuntary Movements
No phaseEnded 1 Dec 2023
No phaseEnded 27 Nov 2023
Stopped early1279 participants
NCT04270604
Biological Sample Collection for Research and Biobanking
Reason given: The study was voluntarily terminated by the PI to focus efforts on an alternative biobanking protocol.
No phaseEnded 16 Nov 2023
Not medical advice. fetched 9 Nov 2026