For volunteers

Healthy volunteer studies in South Africa

35 open studies in the registries that take healthy volunteers and have a site in South Africa.

Phase 1Starts 30 Mar 2027
Up to age 7All sexes22 participants
NCT06613789
Safety & Immunogenicity of 426c.Mod.Core-C4b Vaccine With 3M-052-AF+Alum in Infants Perinatally Exposed to HIV But Uninfected
Soweto · HIV Vaccine Trials Network
Registry updated 18 Sept 2026
Registry record: ClinicalTrials.gov
No phaseStarts 1 Aug 2026
Ages 18 to 28All sexes60 participants
NCT07741474
Community Popular Opinion Leader Intervention for HIV Prevention Uptake in Rural South Africa
uMkhanyakude · Africa Health Research Institute
Registry updated 3 Aug 2026
Registry record: ClinicalTrials.gov
Phase 2Starts 1 Sept 2026
Ages 18 to 55All sexes126 participants
NCT07675629
Evaluating the Safety and Immunogenicity of Polyvalent DNA and Recombinant gp120 Protein HIV Vaccine (PDPHV) in Healthy, HIV-uninfected Adults
Cape Town · Worcester HIV Vaccine
Registry updated 30 Jun 2026
Registry record: ClinicalTrials.gov
No phaseStarts 1 Jul 2026
Ages 16 to 24Women only2100 participants
NCT07666139
The 'Comprehensive Adherence Resource and Empowerment Support' (CARES) Study
Cape Town · RTI International
Registry updated 26 Jun 2026
Registry record: ClinicalTrials.gov
No phaseStarts 29 Jan 2026
Ages 15 to 35All sexes3700 participants
NCT07390409
ALIGN: A Non-randomised Study Delivering Injectable Lenacapavir for HIV Prevention Within a Pre-exposure Prophylaxis (PrEP) Choice Context in Cape Town, South Africa.
Cape Town · Desmond Tutu HIV Foundation
Registry updated 5 Feb 2026
Registry record: ClinicalTrials.gov
Phase 2Starts 30 Jan 2024
Ages 12 to 55All sexes276 participants
NCT05947890
Evaluating the Safety and Immunogenicity of MTBVAC
Rustenburg, Soshanguve, Westdene, Cape Town, Durban, Johannesburg, Isipingo, Klerksdorp · HIV Vaccine Trials Network
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.gov
No phaseStarts 25 Nov 2024
From age 18All sexes230907 participants
NCT06483854
Healer-initiated HIV Counseling and Testing Versus Standard of Care in Rural South Africa
Agincourt · Vanderbilt University Medical Center
Registry updated 23 Oct 2026
Registry record: ClinicalTrials.gov
Phase 1Starts 21 Oct 2026
Ages 18 to 55All sexes66 participants
NCT07883226
A Phase 1 Multiple Dose Trial in Healthy Adult Participants to Evaluate the Safety, Tolerability, Drug-Drug Interactions, and Pharmacokinetics of TBD11
Bloemfontein · Gates Medical Research Institute
Registry updated 22 Oct 2026
Registry record: ClinicalTrials.gov
Phase 3Starts 10 Nov 2025
Ages 16 to 30Women only4580 participants
NCT07071623
A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)
Durban, Johannesburg, Verulam, Pretoria, Cape Town, Phoenix, Chatsworth, Ladysmith · Merck Sharp & Dohme LLC
Registry updated 20 Oct 2026
Registry record: ClinicalTrials.gov
No phaseStarts 26 Jan 2024
Up to age 65All sexes2100 participants
NCT05989802
Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and Assessing Diagnostics At POC for TB in Children (ADAPT for Kids)
Cape Town · University of California, San Francisco
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.gov
Phase 1Starts 4 Aug 2026
Ages 18 to 50All sexes126 participants
NCT07698600
A Clinical Trial to Look at the Safety and Immune Responses of the RNA-based Vaccine BNT168 in Adults Living With or Without HIV
Johannesburg · BioNTech SE
Registry updated 14 Oct 2026
Registry record: ClinicalTrials.gov
No phaseStarts 18 Dec 2025
From age 18All sexes1000 participants
NCT07563309
A Study to Evaluate Performance, Usability, and Contrived Result Interpretation of TruPlex HIV/HepB/Syphilis Rapid Test
Durban, Cape Town, Johannesburg · bioLytical Laboratories
Registry updated 2 Oct 2026
Registry record: ClinicalTrials.gov
No phaseStarts 27 Jul 2026
From age 18All sexes600 participants
NCT07703891
Evaluating the Impact of Using the B-OK Bottles for HIV and ART Literacy in South Africa
Johannesburg · University of Pennsylvania
Registry updated 27 Aug 2026
Registry record: ClinicalTrials.gov
No phaseStarts 17 Apr 2025
From age 15Women only118 participants
NCT05624931
Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
Cape Town · Boston University Charles River Campus
Registry updated 17 Jul 2026
Registry record: ClinicalTrials.gov
Phase 3Starts 27 Feb 2024
Ages 15 to 30All sexes2052 participants
NCT06250504
Long-Acting HIV Pre-Exposure Prophylaxis Integrated With Sexual and Reproductive Health - cRCT
Somkele · Africa Health Research Institute
Registry updated 9 Jul 2026
Registry record: ClinicalTrials.gov
No phaseStarts 1 Dec 2016
Ages 25 to 75Women only1500 participants
NCT02956031
Screening Study for Cervical Pre-cancer and Cancer Prevention in South African Women.
Pretoria · University of Pretoria
Registry updated 7 Jul 2026
Registry record: ClinicalTrials.gov
No phaseStarts 1 Sept 2025
From age 16Women only100 participants
NCT06962592
Mentor Moms+ Study
Cape Town, Saldanha Bay · University of California, Los Angeles
Registry updated 2 Jul 2026
Registry record: ClinicalTrials.gov
No phaseStarts 18 Nov 2024
From age 18All sexes400 participants
NCT06027671
Structured Peer-delivered ART and Reentry Community Strategy
Johannesburg · Johns Hopkins University
Registry updated 2 Jun 2026
Registry record: ClinicalTrials.gov
No phaseStarts 1 Dec 2025
From age 18Men only60 participants
NCT07226323
Testing the WeCare Intervention to Address Mental Health and Medication Adherence Challenges Among MSM in South Africa
Johannesburg · Emory University
Registry updated 29 May 2026
Registry record: ClinicalTrials.gov
No phaseStarts 7 Mar 2023
From age 18All sexes360 participants
NCT05633056
An Adaptive Randomized Controlled Trial
Durban · Columbia University
Registry updated 28 May 2026
Registry record: ClinicalTrials.gov
Phase 1/2Starts 15 Apr 2026
Up to age 10All sexes44 participants
NCT07275606
A Study to Investigate Cabotegravir for Neonates Exposed to HIV-1
Parow Valley · ViiV Healthcare
Registry updated 19 May 2026
Registry record: ClinicalTrials.gov
No phaseStarts 4 Mar 2021
Ages 18 to 60All sexes150 participants
NCT04700579
Pre- and Post-treatment Lung Microbiota, Metabolome and Immune Signatures at the Site of Disease in Patients With Active Pulmonary Tuberculosis
Cape Town · University of Stellenbosch
Registry updated 6 May 2026
Registry record: ClinicalTrials.gov
No phaseStarts 30 Sept 2025
From age 18All sexes2480 participants
NCT06857071
Expanded Social Network Recruitment to HIV Testing (E-SNRHT) Intervention to Locate Undiagnosed Cases and Reduce HIV-related Stigma
Pietermaritzburg · University of Illinois Chicago
Registry updated 13 Apr 2026
Registry record: ClinicalTrials.gov
No phaseStarts 1 Apr 2024
Ages 5 to 18All sexes22464 participants
NCT05982847
National Blood Pressure Screening in Children to Improve Paediatric Healthcare in South Africa
Johannesburg, Port Elizabeth, Cape Town, Mthatha, Polokwane, Bloemfontein, Potchefstroom, Durban · North-West University, South Africa
Registry updated 7 Apr 2026
Registry record: ClinicalTrials.gov
No phaseStarts 9 Feb 2026
Ages 12 to 19All sexes720 participants
NCT06721078
Evaluation of Long-Acting Injectable (LAI) and Teen Clubs in Adolescents (ATTUNE).
Pretoria, Johannesburg, Cape Town, Mtubatuba, Durban · Africa Health Research Institute
Registry updated 3 Apr 2026
Registry record: ClinicalTrials.gov
No phaseStarts 24 Jul 2025
Ages 18 to 35Women only70 participants
NCT07081152
Iron Absorption and Losses in Young South African Women Living Without and With Overweight and Obesity
Potchefstroom · Linda Malan
Registry updated 23 Mar 2026
Registry record: ClinicalTrials.gov
No phaseStarts 19 Mar 2026
From age 18All sexes120 participants
NCT07194902
HIV Self-testing for Partners of HIV-uninfected Postpartum Women
Durban · Massachusetts General Hospital
Registry updated 23 Mar 2026
Registry record: ClinicalTrials.gov
No phaseStarts 29 Sept 2021
From age 18Men only2130 participants
NCT04895839
Predictors of Mental Health in Men With Prostate Cancer Undergoing a Patient Empowerment Program
Ga-Rankuwa, Johannesburg · Gabriela Ilie
Registry updated 18 Mar 2026
Registry record: ClinicalTrials.gov
Phase 1Starts 28 Jul 2025
Ages 18 to 50All sexes120 participants
NCT06617091
A Trial of a Gorilla Adenovirus Vectored Networked Epitopes Vaccine, Administered to Healthy Adults Living Without and With HIV.
Cape Town, Mtubatuba · International AIDS Vaccine Initiative
Registry updated 13 Feb 2026
Registry record: ClinicalTrials.gov
No phaseStarts 19 Jan 2026
From age 12All sexes2000 participants
NCT06408142
Universal Test and Connect for HIV Service Delivery in South Africa
Cape Town · Johns Hopkins University
Registry updated 30 Jan 2026
Registry record: ClinicalTrials.gov
Phase 2Starts 4 Apr 2024
Ages 2 to 45All sexes1040 participants
NCT06306196
Immunogenicity and Safety of Hecolin® in HIV Positive/Negative Adults and in Children
Ga-Rankuwa, Johannesburg, Paarl · International Vaccine Institute
Registry updated 29 Apr 2025
Registry record: ClinicalTrials.gov
Phase 3Starts 17 Oct 2022
Ages 5 to 7All sexes7120 participants
NCT04975178
Efficacy, Safety and Immunogenicity Evaluation of MTBVAC in Newborns in Sub-Saharan Africa
Worcester · Biofabri, S.L
Registry updated 10 Feb 2025
Registry record: ClinicalTrials.gov
No phaseStarts 13 Feb 2024
From age 15All sexes1800 participants
NCT06807736
PrEPared to Choose (PtC) is an Implementation Study of the Delivery of Cabotegravir Long-acting, an Injectable Pre-exposure Prophylaxis (PrEP) Option for HIV Prevention. Injectable PrEP Will be Offered Alongside Oral and Vaginal Ring PrEP From Within a Real-world Context in Cape Town, South Africa.
Cape Town · Desmond Tutu HIV Foundation
Registry updated 4 Feb 2025
Registry record: ClinicalTrials.gov
No phaseStarts 31 Mar 2023
From age 15Men only3642 participants
NCT05602376
Improving HIV Testing, Linkage, and Retention in Care for Men Through U=U Messaging
East London, Cape Town · Desmond Tutu HIV Foundation
Registry updated 1 Nov 2024
Registry record: ClinicalTrials.gov
No phaseStarts 11 Aug 2023
Ages 0 to 50All sexes200 participants
NCT05923333
B. Infantis Supplementation to Improve Immunity in Infants Exposed to HIV
Cape Town · University of Cape Town
Registry updated 22 Aug 2024
Registry record: ClinicalTrials.gov

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