Long COVID and ME/CFS: trials for referral
192 open trials in the registries we read. Each row links to its registry record.
Registry data only. Frontlight does not judge whether a patient can take part: the trial team decides.
Where the open trials are
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192 trials shown
Phase 11 site
Not yet recruitingUnited States
NCT07388550
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
National Institute of Neurological Disorders and Stroke (NINDS)
Registry updated 6 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited Kingdom
NCT07874217
Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study
Oxford Brookes University
Registry updated 5 Nov 2026
Registry record: ClinicalTrials.govPhase 313 sites
Not yet recruitingUnited States
NCT07916259
The Study of Brave-LC LDN Treatment Trial
National Institute of Allergy and Infectious Diseases (NIAID)
Registry updated 4 Nov 2026
Registry record: ClinicalTrials.govPhase 21 site
By invitation onlyUnited States
NCT05350774
Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
National Institute of Neurological Disorders and Stroke (NINDS)
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 31 site
Not yet recruitingCanada
NCT06907251
Dapagliflozin for Long COVID Syndrome
Ottawa Heart Institute Research Corporation
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingUnited States
NCT07597902
SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction
Icahn School of Medicine at Mount Sinai
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
By invitation onlyUnited States
NCT07600320
Fareon Open Label Device Clinical Trial
Icahn School of Medicine at Mount Sinai
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govPhase 20 sites
Not yet recruiting
NCT07899346
Study of VYD2311 for the Treatment of Adults With Long-COVID or Post-Vaccination Syndrome
Invivyd, Inc.
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingTaiwan
NCT05764538
DAOIB for the Treatment of Brain Fog
Chang Gung Memorial Hospital
Registry updated 23 Oct 2026
Registry record: ClinicalTrials.govNo phase3 sites
RecruitingCanada
NCT06928506
Effect of Hi-OxSR for the Treatment of Post COVID Condition
University Health Network, Toronto
Registry updated 22 Oct 2026
Registry record: ClinicalTrials.govPhase 1/20 sites
Not yet recruiting
NCT07682402
Taurine Supplementation in Adolescents With Post-COVID Condition
University of Alberta
Registry updated 16 Oct 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingUnited States
NCT06366724
LIFT: Life Improvement Trial
Brigham and Women's Hospital
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.govNo phase2 sites
RecruitingSpain
NCT05780450
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
Fundación Universidad Católica de Valencia San Vicente Mártir
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingPakistan
NCT07546539
Photobiomodulation in Chronic Fatigue Syndrome
University of Lahore
Registry updated 8 Oct 2026
Registry record: ClinicalTrials.govPhase 21 site
Not yet recruitingUnited States
NCT07285473
Low-Dose Naltrexone For ME/CFS: Dose-Finding
University of Alabama at Birmingham
Registry updated 8 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingGermany
NCT07197138
IMPACT-D+: Immune-Modulating and Psychometric Effects of Accelerated TMS in Depression Plus Comorbid Post-COVID-19 Condition
Max-Planck-Institute of Psychiatry
Registry updated 7 Oct 2026
Registry record: ClinicalTrials.govPhase 310 sites
RecruitingBrazil, Canada, Italy, Uganda, United States, South Africa
NCT06928272
Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study
Douglas D. Fraser
Registry updated 6 Oct 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingUnited States
NCT07021794
SARS-CoV-2 Specific Monoclonal Antibody for Post-COVID-19 Conditions (Long COVID)
Nancy Klimas
Registry updated 29 Sept 2026
Registry record: ClinicalTrials.govPhase 317 sites
RecruitingUnited States
NCT06631287
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
Wes Ely
Registry updated 25 Sept 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingUnited States
NCT07123727
A Study to Examine Anktiva for the Treatment of COVID-19.
ImmunityBio, Inc.
Registry updated 24 Sept 2026
Registry record: ClinicalTrials.govPhase 2/31 site
RecruitingHong Kong
NCT06739720
RCT of Efficacy and Safety of CP003 on CFS/ME or Post COVID-19 Fatigue
The University of Hong Kong
Registry updated 21 Sept 2026
Registry record: ClinicalTrials.govPhase 2/35 sites
RecruitingCanada
NCT06721949
Taurine Supplementation in Long COVID
University of Alberta
Registry updated 18 Sept 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingSpain
NCT07530757
SuperCAP Program to Improve Cognition and Daily Functioning in Post-COVID-19 Condition
Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Registry updated 11 Sept 2026
Registry record: ClinicalTrials.govPhase 40 sites
Not yet recruiting
NCT07240649
Emerging Indications for Hyperbaric Oxygen Treatment
Jay C. Buckey Jr.
Registry updated 9 Sept 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingIsrael
NCT07621068
Hyperbaric Oxygen Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Assaf-Harofeh Medical Center
Registry updated 21 Aug 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingNetherlands
NCT07298005
Sonlicromanol in Post-COVID
Michele van Vugt
Registry updated 18 Aug 2026
Registry record: ClinicalTrials.govPhase 21 site
Not yet recruitingGermany
NCT07724834
CD19-B Cell Depletion in PAIS-ME/CFS Patients
Charite University, Berlin, Germany
Registry updated 24 Jul 2026
Registry record: ClinicalTrials.govNo phase0 sites
Not yet recruiting
NCT07709234
Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue
University of Las Palmas de Gran Canaria
Registry updated 22 Jul 2026
Registry record: ClinicalTrials.govPhase 21 site
Not yet recruitingGermany
NCT07714213
Post-acute Infectious Syndrome - Aripiprazole Symptom Evaluation (PAIS-AriSE)
Christiana Franke
Registry updated 20 Jul 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingUnited States
NCT06940609
Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation
University of New Mexico
Registry updated 15 Jul 2026
Registry record: ClinicalTrials.gov
The same sites as a list
- United States68 open trials
- Germany16 open trials
- Canada14 open trials
- Spain11 open trials
- Netherlands11 open trials
- Italy7 open trials
- China6 open trials
- France5 open trials
- Switzerland5 open trials
- United Kingdom4 open trials
- Taiwan4 open trials
- Brazil4 open trials
- Austria4 open trials
- Norway3 open trials
- Sweden3 open trials
- Hong Kong2 open trials
- Poland2 open trials
- Greece2 open trials
- Portugal2 open trials
- Luxembourg2 open trials
- Denmark2 open trials
- Türkiye2 open trials
- Mexico2 open trials
- Pakistan1 open trial
- Uganda1 open trial
- South Africa1 open trial
- Zambia1 open trial
- Israel1 open trial
- Thailand1 open trial
- Japan1 open trial
- Jordan1 open trial
- Saudi Arabia1 open trial
- United Arab Emirates1 open trial
- Australia1 open trial
- Belgium1 open trial
- Colombia1 open trial
- Uzbekistan1 open trial
- Lithuania1 open trial
- Finland1 open trial
Who treats this
Institutions with trials or publications in this disease (OpenAlex, registries). Institutions only, no people.
What changed in the last 7 days
Registry facts, one per line, newest first.
New in the registry
A Complex Intervention for Chronically Fatigued Lymphoma Survivors
NCT05130099 · No phase · Norway
Source: ClinicalTrials.govOpened for recruitment
Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study
NCT07874217 · No phase · United Kingdom
Source: ClinicalTrials.govOpened for recruitment
The Effect of Allopurinol on the Risk of Cardiovascular Events in Patients with Cardiovascular Risk
NCT05943821 · Phase 3 · Poland
Source: ClinicalTrials.govStatus changed: Completed → Running, not recruiting
NCT05697640 · Phase 2 · Germany
Source: ClinicalTrials.govClosed for recruitment
The Effect of Allopurinol on the Risk of Cardiovascular Events in Patients with Cardiovascular Risk
NCT05943821 · Phase 3 · Poland
Source: ClinicalTrials.govClosed for recruitment
Epigenetic Changes in Long COVID Patients
NCT07757620 · No phase · Italy
Source: ClinicalTrials.govNew in the registry
The Study of Brave-LC LDN Treatment Trial
NCT07916259 · Phase 3 · United States
Source: ClinicalTrials.gov
New reviews, guidelines and randomised trials in PubMed
Meta-analysis
Ciencia & saude coletiva · PubMed
Results card
Trials that finished or stopped in the last 3 years, with the reason the registry gives and linked publications.
No phaseEnded Sept 2026
Withdrawn before start0 participants
NCT07714889
Development of an Accessible Cognitive Behavioral Therapy Digital Therapeutic for Individuals With Long COVID
Reason given: This study does not meet the clinical trial definition under FDAAA 801 / NIH policy - participants aren't prospectively assigned to an intervention, and no biomedical or behavioral outcome is evaluated.
Phase 2Ended 29 Sept 2026
Completed90 participants
NCT06766825
Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC)
Phase 2Ended 2 Sept 2026
Phase 2Ended 1 Sept 2026
Completed57 participants
NCT06822179
Effectiveness of a Personalized In-home Telerehabilitation Program on Self-Care in Patients With Long COVID
No phaseEnded 1 Sept 2026
No phaseEnded 21 Aug 2026
Completed59 participants
NCT05131594
Evaluating the Response of the Immune System of People With Long COVID (Post SARS-CoV-2)
No phaseEnded 14 Aug 2026
Completed40 participants
NCT07005921
QEEG-NEUROFEEDBACK FOR COGNITIVE REHABILITATION IN LONG COVID-19 SURVIVORS WITH BRAIN FOG
No phaseEnded 7 Aug 2026
Completed9 participants
NCT07621588
Diaphragmatic Breathing Exercises With KOTS Currents in Patients With Long COVID
No phaseEnded 31 Jul 2026
Stopped early13 participants
NCT05530317
CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19
Reason given: PI changed institutions, exploring restarting at new institution
Phase 2Ended 2 Jul 2026
No phaseEnded 30 Jun 2026
Completed237 participants
NCT07005947
Long COVID-19 Cutaneous Signatures: An ARPA Funded Research Project
Phase 2Ended 23 Jun 2026
Completed400 participants
2024-517199-39-00
A trial to find the effect of Ginkgo biloba extract EGb 761® and how safe it is in participants with cognitive impairment associated with post COVID-19 syndrome
Phase 2Ended 22 Jun 2026
Phase 2Ended 22 Jun 2026
Completed20 participants
NCT06821087
Evaluating the Neuromodulatory Effect of Ketamine in Long COVID-19
No phaseEnded 20 Jun 2026
Completed400 participants
NCT07435805
Long-Term Health Effects of Previous Coronavirus Disease 2019 (COVID-19) in Patients Undergoing Preoperative Anesthesia Evaluation
Phase 2Ended 18 Jun 2026
No phaseEnded 1 Jun 2026
Completed47 participants
NCT07888673
Transcraneal Magnetic Stimulation for Treatment of Non-nociceptive Pain in Chronic Diseases
No phaseEnded 1 Jun 2026
No phaseEnded 31 May 2026
Stopped early1 participant
NCT05876377
Use and Effectiveness of COVID-19 Vaccines Using State Vaccine Registries and Insurance Claims Data
Reason given: Study discontinued due to questions of data validity and bias in data which would limit causal inference and estimation of vaccine effectiveness.
No phaseEnded May 2026
Withdrawn before start0 participants
NCT06082258
Education of Medical Staff to Post Acute Covid susTained sYmptoms
Reason given: The research was not feasible due to administrative and organizational constraints.
Show more
No phaseEnded 27 May 2026
Completed195 participants
NCT06042751
Psychosomatic, Physical Activity or Both for Post-covid19 Syndrom
No phaseEnded 6 May 2026
Completed196 participants
NCT05781893
Basel Long COVID-19 Cohort Study and Digital Long COVID Substudy
No phaseEnded 5 May 2026
Completed360 participants
NCT06404060
RECOVER-ENERGIZE Platform Protocol_Appendix A (Exercise Intolerance)
- Rationale and Design of RECOVER-ENERGIZE: A Platform Clinical Trial of Interventions for Exercise Intolerance With and Without Post-exertional Malaise in Long COVID. · medRxiv : the preprint server for health sciences, 2026
Phase 2Ended 20 Apr 2026
No phaseEnded 20 Apr 2026
Phase 2Ended 1 Apr 2026
Early Phase 1Ended 31 Mar 2026
No phaseEnded 13 Mar 2026
No phaseEnded 1 Mar 2026
Completed18 participants
NCT06503913
Cognitive Muscular Therapy for Patients With Long-COVID and Breathing Pattern Disorder
No phaseEnded 1 Mar 2026
Phase 2Ended 28 Feb 2026
Phase 2Ended 19 Feb 2026
Stopped early96 participants
NCT05986422
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS)
Reason given: Following a recommendation from the Data Safety Monitoring Board (DSMB).
No phaseEnded 29 Jan 2026
Completed40 participants
NCT07880171
Intensive Home-based Transcranial Direct Current Stimulation for Long COVID
No phaseEnded Dec 2025
Withdrawn before start0 participants
NCT05467904
Double-Blind Randomized Placebo-Controlled Trial of a Proprietary Full Hemp Flower Formulation for Long COVID
Reason given: lack of funding
Phase 2/3Ended 31 Dec 2025
Completed460 participants
NCT05513560
RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine
No phaseEnded 31 Dec 2025
Completed60 participants
NCT06118138
Hyperbaric High Pressure Oxygen Therapy in Post-COVID Syndrome and ME/CFS
- Hyperbaric oxygen therapy improves clinical symptoms and functional capacity and modulates thalamic connectivity in ME/CFS: a prospective cohort study. · Journal of translational medicine, 2026
Phase 2Ended 31 Dec 2025
No phaseEnded 30 Dec 2025
Completed40 participants
NCT07046442
Effect of Pulmonary Rehabilitation and Physical Activity on COVID-19 Long-Term Symptoms (PuReCOVID)
Phase 2Ended 29 Dec 2025
Phase 2Ended 17 Dec 2025
No phaseEnded 14 Dec 2025
Completed15 participants
NCT06974058
Study to Investigate the Health Benefits of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms
- Potential Adjunctive Effects of Quercetin-Curcumin Co-Supplementation in Adults with Mild-to-Moderate Long COVID: Results from a Pragmatic Exploratory Real-World Clinical Study. · Pharmaceuticals (Basel, Switzerland), 2026
No phaseEnded 13 Dec 2025
No phaseEnded 11 Dec 2025
No phaseEnded 1 Dec 2025
No phaseEnded 1 Dec 2025
Completed30 participants
NCT06739668
Humanity Neurotech Device Clinical Trial in Adults With Long COVID Cognitive Dysfunction
No phaseEnded 30 Nov 2025
No phaseEnded 30 Nov 2025
Early Phase 1Ended Nov 2025
Withdrawn before start0 participants
NCT05371288
The Role of Glutathione Deficiency and MSIDS Variables in Long COVID-19
Reason given: No longer studying long COVID
No phaseEnded 17 Nov 2025
Completed300 participants
NCT06404073
RECOVER-ENERGIZE Platform Protocol_Appendix B (Structured Pacing (PEM))
- Rationale and Design of RECOVER-ENERGIZE: A Platform Clinical Trial of Interventions for Exercise Intolerance With and Without Post-exertional Malaise in Long COVID. · medRxiv : the preprint server for health sciences, 2026
No phaseEnded 3 Nov 2025
Completed62 participants
NCT05758480
Characterization of the Immunometabolic Signature in Long COVID-19.
No phaseEnded 31 Oct 2025
Completed15172 participants
NCT05172024
Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)
Phase 2Ended 30 Oct 2025
Completed132 participants
2024-516174-30-01
Investigation of treating chronic fatigue syndrome after COVID with pharmacotherapy (pregabalin) or complex rehabilitation
No phaseEnded 30 Oct 2025
Completed660 participants
NCT06404047
RECOVER-ENERGIZE Platform Protocol
- Rationale and Design of RECOVER-ENERGIZE: A Platform Clinical Trial of Interventions for Exercise Intolerance With and Without Post-exertional Malaise in Long COVID. · medRxiv : the preprint server for health sciences, 2026
No phaseEnded 8 Oct 2025
Completed66 participants
NCT05710770
Immunoadsorption in Patients With Chronic Fatigue Syndrome Including Patients With Post-COVID-19 CFS
No phaseEnded 6 Oct 2025
Completed86 participants
NCT05798221
Complementary Self-help Strategies for Patients With Post-COVID-19 Syndrome
No phaseEnded 1 Oct 2025
No phaseEnded 1 Oct 2025
Completed80 participants
NCT07397130
Inspiratory Muscle Pressure and Diaphragmatic Strength in Women With Long COVID-19: A Pressure Biofeedback-Guided Training Study
Phase 2Ended 1 Oct 2025
Withdrawn before start0 participants
NCT06234462
A Study of Amantadine for Cognitive Dysfunction in Patients With Long-Covid
Reason given: challenges with recruitment
Phase 2Ended 30 Sept 2025
Completed16 participants
NCT06437223
Study of Xiflam™ Treatment in Patients Post COVID-19 Infection Suffering From What is Known as Long COVID (LC)
No phaseEnded 30 Sept 2025
Not medical advice. fetched 10 Nov 2026