Frontotemporal dementia: trials for referral
116 open trials in the registries we read. Each row links to its registry record.
Registry data only. Frontlight does not judge whether a patient can take part: the trial team decides.
Where the open trials are
Type a city to sort by distance. The distance is worked out in your browser; the city is not sent anywhere.
116 trials shown
No phase1 site
RecruitingUnited States
NCT03225144
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
National Institute of Neurological Disorders and Stroke (NINDS)
Registry updated 5 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingItaly
NCT07906769
Automated Language Analysis in Neurodegenerative Diseases: Application of Artificial Intelligence Models
Istituti Clinici Scientifici Maugeri SpA
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 110 sites
RecruitingUnited Kingdom, Japan, United States
NCT06297590
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
Eli Lilly and Company
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT01793168
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Sanford Health
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruitingUnited States
NCT07511179
Personalized Closed-Loop Brain Stimulation for Patients With Primary Progressive Aphasia
Johns Hopkins University
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.govPhase 11 site
RecruitingSpain
2025-524480-21-00
The clinical trial to study a new drug, AP-2.
Molefy Pharma S.L.
Registry updated 27 Oct 2026
Registry record: EU CTISNo phase2 sites
RecruitingItaly
NCT06739967
Speech and Language Interventions for Italian People With PPA
Istituti Clinici Scientifici Maugeri SpA
Registry updated 26 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT00344331
Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Registry updated 26 Oct 2026
Registry record: ClinicalTrials.govPhase 2/30 sites
Not yet recruiting
NCT07885917
Long-Term Safety and Tolerability of Nizubaglustat in Participants With Rare Lysosomal Disorders
Azafaros B.V.
Registry updated 21 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT05588167
Establishment of Genomic and Phenotypic Database for Niemann-Pick Disease, Type C
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingFrance
NCT06985212
National Multicentre Study of the Natural History of Acid Sphingo-myelinase Deficiency in Adults and Children
Wladimir MAUHIN, Dr
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.govNo phase2 sites
Not yet recruitingUnited States
NCT07569367
A Wearable Sensor Platform for Remote Monitoring of Individuals on the Frontotemporal Dementia Spectrum
BioSensics
Registry updated 13 Oct 2026
Registry record: ClinicalTrials.govPhase 20 sites
Not yet recruiting
NCT07868328
A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of NIO752 in Primary Tauopathies
Novartis Pharmaceuticals
Registry updated 9 Oct 2026
Registry record: ClinicalTrials.govNo phase26 sites
RecruitingCanada, United States
NCT04363684
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Mayo Clinic
Registry updated 7 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingItaly
NCT07854327
Restoring Cervical Lymphatic Drainage in Alzheimer's Disease
University of Siena
Registry updated 2 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingFinland
NCT05326750
Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases
Kuopio University Hospital
Registry updated 2 Oct 2026
Registry record: ClinicalTrials.govNo phase65 sites
By invitation onlyCanada, United States
NCT05617014
Alzheimer's Disease Neuroimaging Initiative 4
University of Southern California
Registry updated 29 Sept 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingItaly
NCT07505784
Transcranial Alternating Current Stimulation in Frontotemporal Dementia
IRCCS Centro San Giovanni di Dio Fatebenefratelli
Registry updated 24 Sept 2026
Registry record: ClinicalTrials.govPhase 31 site
RecruitingUnited States
NCT05456503
PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620
University of Pennsylvania
Registry updated 21 Sept 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingAustralia
NCT06823752
A Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia.
Woolcock Institute of Medical Research
Registry updated 18 Sept 2026
Registry record: ClinicalTrials.govNo phase3 sites
RecruitingCanada
NCT06051123
Effects of Probiotics in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Spectrum Disorder (ALS-FTDSD) Patients
Centre hospitalier de l'Université de Montréal (CHUM)
Registry updated 17 Sept 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT03887481
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
Johns Hopkins University
Registry updated 9 Sept 2026
Registry record: ClinicalTrials.govNo phase2 sites
RecruitingUnited States
NCT07260253
Remotely-supervised Neuromodulation in PPA
Maya Henry
Registry updated 4 Sept 2026
Registry record: ClinicalTrials.govPhase 11 site
RecruitingUnited States
NCT02254863
UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells
Joanne Kurtzberg, MD
Registry updated 3 Sept 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruitingDenmark
NCT07200739
Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)
Zealand University Hospital
Registry updated 2 Sept 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingItaly
NCT06596746
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
Casa di Cura San Raffaele Cassino
Registry updated 2 Sept 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT07798700
Biofluid Research on Age-Related or Inherited Neurodegeneration
University of Pennsylvania
Registry updated 1 Sept 2026
Registry record: ClinicalTrials.govEarly Phase 11 site
RecruitingNetherlands
NCT06891716
[18F]ACI-19626 PET in TDP-43 Proteinopathies
AC Immune SA
Registry updated 26 Aug 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT06377033
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
University of Pennsylvania
Registry updated 14 Aug 2026
Registry record: ClinicalTrials.govPhase 1/220 sites
RecruitingBelgium, Canada, Spain, United Kingdom, Italy, Netherlands
NCT06064890
A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
AviadoBio Ltd
Registry updated 13 Aug 2026
Registry record: ClinicalTrials.gov
The same sites as a list
- United States53 open trials
- Italy13 open trials
- France13 open trials
- Canada12 open trials
- Spain7 open trials
- United Kingdom4 open trials
- Sweden4 open trials
- Australia3 open trials
- Netherlands3 open trials
- China3 open trials
- Belgium2 open trials
- Czechia2 open trials
- Switzerland2 open trials
- Japan1 open trials
- Finland1 open trials
- Denmark1 open trials
- Poland1 open trials
- United Arab Emirates1 open trials
- Germany1 open trials
- Slovakia1 open trials
- Hong Kong1 open trials
- Mexico1 open trials
- Brazil1 open trials
Who treats this
Institutions with trials or publications in this disease (OpenAlex, registries). Institutions only, no people.
Amsterdam UMC Location Vrije Universiteit Amsterdam
Amsterdam, Netherlands
0 trials · 61 publications · ROR
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Brescia, Italy
2 trials · 20 publications · ROR
Biogipuzkoa Health Research Institute
Donostia / San Sebastian, Spain
0 trials · 21 publications · ROR
Biomedical Research Networking Center on Neurodegenerative Diseases
Madrid, Spain
0 trials · 61 publications · ROR
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
1 trials · 22 publications · ROR
Consejo Nacional de Investigaciones Científicas y Técnicas
Buenos Aires, Argentina
0 trials · 46 publications · ROR
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Barcelona, Spain
0 trials · 27 publications · ROR
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy
2 trials · 50 publications · ROR
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
São Paulo, Brazil
0 trials · 25 publications · ROR
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Mexico City, Mexico
0 trials · 25 publications · ROR
National Hospital for Neurology and Neurosurgery
London, United Kingdom
0 trials · 38 publications · ROR
National Institute of Mental Health and Neurosciences
Bengaluru, India
0 trials · 18 publications · ROR
National Institute of Neurological Disorders and Stroke
Bethesda, United States
0 trials · 31 publications · ROR
The University of Texas at San Antonio Health Science Center
San Antonio, United States
2 trials · 20 publications · ROR
The University of Texas Southwestern Medical Center
Dallas, United States
0 trials · 18 publications · ROR
UCSF Edward and Pearl Fein Memory and Aging Center
San Francisco, United States
1 trials · 38 publications · ROR
University of California, San Francisco
San Francisco, United States
8 trials · 223 publications · ROR
University of Massachusetts Chan Medical School
Worcester, United States
0 trials · 21 publications · ROR
University of North Carolina at Chapel Hill
Chapel Hill, United States
0 trials · 22 publications · ROR
What changed in the last 7 days
Registry facts, one per line, newest first.
Phase changed: Phase 1 → Early Phase 1
[18F]ACI-19626 PET in TDP-43 Proteinopathies
NCT06891716 · Early Phase 1 · Netherlands
Source: ClinicalTrials.govPhase changed: No phase → Phase 1
In Vivo PET of Synaptic Density in Cognitive Disorders
NCT05384353 · Phase 1 · Belgium
Source: ClinicalTrials.gov
New reviews, guidelines and randomised trials in PubMed
Meta-analysis
Alzheimer's & dementia : the journal of the Alzheimer's Association · PubMed
Results card
Trials that finished or stopped in the last 3 years, with the reason the registry gives and linked publications.
No phaseEnded 31 May 2026
Completed278 participants
NCT05437159
Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech
No phaseEnded 16 May 2026
Completed44 participants
NCT04865172
ECOCAPTURE for the Assessment of Apathy Under Real-life Conditions
Phase 1/2Ended 7 May 2026
Phase 2Ended 5 May 2026
No phaseEnded 22 Mar 2026
No phaseEnded 6 Mar 2026
Phase 3Ended 6 Jan 2026
Completed79 participants
NCT04374136
A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3)
No phaseEnded 31 Dec 2025
No phaseEnded 15 Aug 2025
Phase 1Ended 5 Aug 2025
Completed6 participants
NCT06705192
Study in Asymptomatic GRN-FTD Patients to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VES001
No phaseEnded 14 Jul 2025
Completed219 participants
NCT06471660
Family Caregiver Online Survey (Dementia and Swallowing Difficulties)
Phase 2Ended 30 Jun 2025
Completed76 participants
NCT04046991
Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS
Phase 1/2Ended 20 Jun 2025
Completed17 participants
NCT05189106
Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial
Phase 1Ended 4 Jun 2025
Phase 2Ended 22 May 2025
Completed327 participants
NCT05063539
A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease
No phaseEnded 25 Apr 2025
Phase 1Ended 28 Feb 2025
No phaseEnded 14 Nov 2024
Completed50 participants
NCT05524181
Telehealth-enabled Integrated Palliative Care for People With Dementia
Phase 2/3Ended 31 Oct 2024
Completed50 participants
NCT02612129
Arimoclomol Prospective Study in Participants Diagnosed With Niemann-Pick Disease Type C
Phase 1/2Ended 4 Oct 2024
Completed4 participants
NCT03471143
Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C
No phaseEnded 31 Aug 2024
No phaseEnded 25 Aug 2024
Phase 4Ended 6 Aug 2024
Completed83 participants
NCT03185208
Lithium As a Treatment to Prevent Impairment of Cognition in Elders
- Low-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial. · JAMA neurology, 2026
Phase 1Ended 1 Aug 2024
Completed81 participants
NCT02736695
Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal Dementia
No phaseEnded 31 Jul 2024
Phase 1Ended 26 Jul 2024
Phase 1Ended 26 Jul 2024
Completed78 participants
NCT06226064
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VES001 in Healthy Participants
No phaseEnded 19 Jul 2024
Completed262 participants
NCT05012410
WeCareAdvisor Study for Caregivers of People Living With Dementia
No phaseEnded 1 Jul 2024
No phaseEnded 30 Jun 2024
Completed84 participants
NCT02675270
Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia
Phase 2Ended 5 Jun 2024
Completed33 participants
NCT03987295
A Phase 2 Study to Evaluate Safety of Long-term AL001 Dosing in Frontotemporal Dementia (FTD) Patients (INFRONT-2)
No phaseEnded 31 May 2024
Completed85 participants
NCT04165213
Care of Persons With Dementia in Their Environments (COPE) in Programs of All-Inclusive Care of the Elderly (PACE)
No phaseEnded 28 May 2024
Completed1141 participants
NCT02854033
Alzheimer's Disease Neuroimaging Initiative 3
- Symptom-Guided Blood Biomarker Testing for Alzheimer's Disease. · Dementia and geriatric cognitive disorders, 2026
No phaseEnded 8 May 2024
Completed66 participants
NCT03272230
Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System
No phaseEnded 3 May 2024
No phaseEnded 22 Apr 2024
Completed495 participants
NCT05916664
Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers
Phase 2Ended 1 Apr 2024
No phaseEnded 31 Mar 2024
No phaseEnded 28 Feb 2024
No phaseEnded 1 Feb 2024
No phaseEnded 29 Jan 2024
Completed48 participants
NCT05508646
Group-Based Telehealth Music Therapy Intervention for Patients With Dementia: A Pilot Study
No phaseEnded 9 Jan 2024
Not medical advice. fetched 6 Nov 2026